Incidence of variant Creutzfeldt-Jakob disease diagnoses and deaths in the UK January 1994 – December 2011
Incidence of variant Creutzfeldt-Jakob disease diagnoses and deaths in the
UK January 1994 – December 2011
N J Andrews, Senior Statistician
Statistics Unit, Centre for Infections, Health Protection Agency
2nd July 2012
Summary
In 2011 there were two new diagnosis of vCJD and five deaths. One of the
new diagnoses related to a death in 2008. This brings the total number of cases
reported in the UK to 176 of whom all 176 have died.
Results from modelling the underlying incidence of diagnoses and deaths
indicate that the epidemic reached a peak in about the year 2000 when there were
27 diagnoses and 28 deaths and has since declined to a current incidence of
about 1 to 2 diagnoses/death per year. There is evidence that the epidemic curve
is skewed with an extended tail. Looking at onsets shows similar results with
evidence of an extended tail.
An analysis that looked at deaths by birth cohort (pre 1970, 1970s, 1980s)
showed that the shape of the epidemic differs between cohorts, mainly due to the
fact that deaths of individuals born in the 1980s were only seen from 1999
onwards. It is important to note that although a peak in cases has been passed,
it is possible that there will be future peaks, possibly in other genetic
groups. To date, however, there is no evidence of a second wave.
There is also the possibility of ongoing person to person spread as seen
with four cases of transfusion association vCJD infection to date, who received
blood in 1999 or earlier from donors who were later diagnosed with clinical
vCJD. Three of these individuals developed vCJD (one diagnosed in 2003 and two
in 2006), whilst the fourth died from causes unrelated to vCJD, but was found on
post mortem examination to have abnormal prion protein present in the spleen and
a lymph node.
SEE STEADY INCREASE OF SPORADIC CJD IN THE U.K. TO 2011, from 28 in 1990,
to 90 cases in 2011, the highest number to date in any given year, for sporadic
CJD. remember, sporadic CJD is not a single strain, but many strains of unknown,
undocumented origin, to date. ...TSS
***Also, a link is suspected between atypical BSE and some apparently
sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases
constitute an unforeseen first threat that could sharply modify the European
approach to prion diseases.
Second threat
snip...
Wednesday, June 27, 2012
First US BSE Case Since 2006 Underscores Need for Vigilance
Neurology Today 21 June 2012
Wednesday, June 13, 2012
MEXICO IS UNDER or MIS DIAGNOSING CREUTZFELDT JAKOB DISEASE AND OTHER PRION
DISEASE SOME WITH POSSIBLE nvCJD
previous USA PRION UNIT reports ;
Saturday, March 5, 2011
MAD COW ATYPICAL CJD PRION TSE CASES WITH CLASSIFICATIONS PENDING ON THE
RISE IN NORTH AMERICA
Sunday, February 12, 2012
National Prion Disease Pathology Surveillance Center Cases Examined1
(August 19, 2011) including Texas
Tuesday, June 26, 2012
Creutzfeldt Jakob Disease Human TSE report update North America, Canada,
Mexico, and USDA PRION UNIT as of May 18, 2012
type determination pending Creutzfeldt Jakob Disease (tdpCJD), is on the
rise in Canada and the USA
Monday, June 11, 2012
Guidance for Industry Draft Guidance for Industry: Amendment to “Guidance
for Industry: Revised Preventive Measures to Reduce the Possible Risk of
Transmission of Creutzfeldt-Jakob Disease and Variant Creutzfeldt-Jakob Disease
by Blood and Blood Products”
Wednesday, April 25, 2012
USA MAD COW DISEASE AND CJD THERE FROM SINGELTARY ET AL 1999 – 2012
posted by Terry S. Singeltary Sr. | 5:01 PM
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